The Informa Conference on Biocatalysis and the Industrial Applications of Enzymes starts today (March 18) with a workshop and goes through Thursday afternoon. David Rozzell is there, speaking today (Tuesday) and chairing the Wednesday session.

The conference has an excellent group of speakers. I’ll be live blogging the conference and available for a meet-up all week. Contact me by email (david@bio-catalyst.com) or just find me at the conference.

David

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Biocatalysis Enzyme GuideBiocatalysis—the use of enzymes to catalyze chemical reactions—has gained in popularity in recent years, and for good reason. Biocatalysis works.

Increasingly, enzymes are among the first choices of catalysts for a chemical reaction, no longer relegated to a back-up strategy to be considered when everything else has failed. The use of enzymes leads to more sustainable chemical manufacturing, often producing products in higher yield and with better purity and lower cost than more traditional alternatives. Further, improving biocatalysts using directed evolution approaches is now a standard methodology, allowing enzymes to be engineered to fit the conditions of a desired reaction in a targeted manner.

The Biocatalysis Enzyme Guide contains comprehensive world-wide listings of companies involved in biocatalysis. Section 1 of the Biocatalysis Enzyme Guide contains profiles 87 different companies developing or selling enzymes for biocatalysis applications, including key contact information. Also included are the services offered by each company, facilitating the identification of the best outsourcing partners. An important aim of the Biocatalysis Enzyme Guide is to provide actionable information on suppliers, developers, and manufacturers of enzymes for biocatalysis so that you will save time in sourcing enzymes and finding biocatalysis partners.

But the Biocatalysis Enzyme Guide includes much more.

Section 2 lists the most important enzymes used for biocatalysis, their alternate names, their applications, and every company around the world that sells or develops this type of enzyme. Each enzyme is identified along with its alternative names and its biocatalysis applications. Every company around the world that offers that type of enzyme is listed in an accompanying Table. Some listings, such as the one for ketoreductases, encompass hundreds of individual enzymes and improved variants that are available from various enzyme companies (by the way, there are 21 different companies described in the Guide supplying Ketoreductases for biocatalysis). Many of these can be purchased in convenient screening sets, allowing a relatively quick search to identify the best enzyme for a target application. Other enzymes, chloroperoxidase being an example, are available as only 1 or 2 types of different enzymes, and are available from only a small number of suppliers. This section allows you to search each enzyme for potential suppliers or developers, and if desired, also for developers of customized or evolved enzymes.

Section 3 focuses on companies that develop or offer immobilized enzymes. Frequently, immobilization is used to improve the economics of a biocatalytic process. Immobilized enzymes can be used in continuous flow or stirred tank systems. In both cases, the ability to stabilize enzymes and permit reuse can bring down the cost contribution of the biocatalyst to a level that makes a process more economical. You may be surprised to know that there are 28 different companies offering immobilized enzymes and custom immobilization services. This section will identify the best suppliers for almost any immobilized enzyme needs, including custom development of an immobilized enzyme formulation.

A fourth section lists companies that provide Biocatalysis Services. For each service area—Enzyme Screening, Custom Enzyme Development, Biocatalytic Process Development, Enzyme Evolution, Contract Manufacturing, and Immobilization—all companies providing that service are listed along with contact information for each company.

The Biocatalysis Enzyme Guide is the only comprehensive listing of 87 biocatalysis enzyme suppliers around the world so that you can identify all options for enzyme supply.

The Biocatalysis Enzyme Guide shows you which companies offer contract research and custom enzyme development services so that you can find the best partners for enzyme screening, new enzyme discovery, enzyme evolution, or biocatalytic process development.

The Biocatalysis Enzyme Guide describes which companies offer contract enzyme manufacturing services to simplify the identification of a biocatalyst supplier at commercial scale.

The Biocatalysis Enzyme Guide highlights the areas of strength and specialization for each enzyme company so that you can find the most suitable business partner for any specific enzyme needs.

The Biocatalysis Enzyme Guide lists all the suppliers of immobilized enzymes and immobilization technology so that you can quickly identify a supplier or research partner for immobilized biocatalyst development.

The Biocatalysis Enzyme Guide is available now for $395.00. We hope you will find the Biocatalysis Enzyme Guide to be the most useful guide available anywhere to biocatalysis enzymes and their developers and producers. To get yours, click the Add to Cart Button below.

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Enzyme Sources Guide: Revised and Updated for 2014, Available Now

January 13, 2014

Tweet New suppliers and developers of enzymes are entering the market, and existing enzyme companies are expanding their offerings and capabilities. Smaller companies are being acquired by larger ones (BASF ‘s acquisition of Verenium or Novozymes’ acquisition of Allopartis are two recent examples), and large companies are merging to create even larger companies (for example: […]

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Aromatic Peroxygenase Structures

January 9, 2014

Tweet Aromatic peroxygenases have catalytic activity similar to that of cytochrome P450 monoxygenases (hydroxylation, S-oxidation, N-oxidation) on both aromatic and aliphatic substrates.  Unlike P450 monooxygenases, these enzymes have no need for NAD(P)H and complicated reductase domains and instead use hydrogen peroxide as the oxidant. The aromatic peroxygenase from the edible commercial mushroom, Agrocybe aegerita, is one of the well-studied enzymes […]

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Better Biocatalyst Reaction Schemes

December 20, 2013

Tweet Biocatalysts are increasingly being used by synthetic chemists.  For some reactions, such as stereoselective ketone reduction or resolution of carboxylic acids and esters, ketoreductases (KREDs) and lipases are well known and a first-line option.  However, there are a wide variety of enzymes that do useful chemistry that are not routinely used within the organic […]

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Omega Transaminase Review

December 19, 2013

Tweet Kroutil and co-workers have published a review on cascade reactions involving omega transaminases.  Cascade strategies are a powerful way to drive the equilibria of transaminase reactions, and the reductive amination of a substrate is often driven by concurrent enzymatic consumption of a co-product.  Many other cascades, for example the oxidation of an alcohol to a carbonyl followed by transaminase-mediated reduction […]

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John Cornforth and Enzyme Stereoselectivity

December 16, 2013

Tweet Sir John Cornforth passed away on December 14th, 2013.  Cornforth was a pioneer in the elucidation of the stereochemistry of enzyme reactions.  A chemist by training, Australian-born Cornforth contributed to the synthesis of steroids while conducting doctoral studies with Sir Robert Robinson at Oxford.  Cornforth’s independent research involved labeling enzyme substrates with deuterium and tritium using synthetic chemistry, generating isotopically-chiral […]

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Let’s Meet at Informex in Miami

December 12, 2013

Tweet Just a quick note to let everyone know that David Rozzell will be at Informex in January. If you would like to schedule a meeting, contact me by email: david@bio-catalyst.com And we have a special offer on the Enzyme Sources Guide through the end of December: All purchasers will get a free updated 2014 […]

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New Mainstream Biocatalysis Newsletter: Profiles on Verenium, Toluene Dioxygenase

December 3, 2013

Tweet The latest Mainstream Biocatalysis Newsletter came out this morning. In this issue we cover the latest company news, publications, and published patent applications. There are also two new profiles. The Company Profile is Verenium Corporation, which is timely since Verenium was recently acquired by BASF. The Enzyme Profile is toluene dioxygenase, an enzyme first […]

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Biocatalytic Retrosynthesis

November 4, 2013

Tweet E. J. Corey pioneered retrosynthetic analysis in organic synthesis, In fact, I was fortunate enough to take his course covering the subject in graduate school, and it was tour-de-force for synthetic organic chemists. Now, with biocatalysis surging and rightly staking a claim to be a viable option for chemical production, couldn’t the Corey concepts […]

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