Biocatalysis

Ethanol, and to a lesser extent biodiesel, have been the only biofuels products of note to be offered thus far. Why? For the simple reason that the technology already existed to make these products at a cost that allowed for commercialization without too large a subsidy. But, if one thinks about the ideal biofuel process, there is a much more attractive option being pursued at a number of early-stage biofuels developers.

Imagine a process that converts carbon dioxide–a greenhouse gas!–into a biofuel while growing in a pond or in sea water. This would be biofuels nirvana, and it may not be too far from becoming a reality.

Here are a few companies to watch.

Aurora Biofuels is using a genetically modified algae developed at the University of California at Berkeley to efficiently produce biodiesel using CO2 as the feedstock. The Aurora claims the technology can create biodiesel fuel competitive with $50 per barrel oil.

Synthetic Genomics approach does not use algae, but rather, specially created micro-organisms that are built by redesigning the genome almost form scratch. The ultimate goal is the conversion of carbon dioxide into fuels or commodity chemicals using energy from the sun to drive the process. Craig Venter, of genome-sequencing fame, leads this effort with up to $300 million in funding form Exxon Mobil. That kind of financial support gives Synthetic Genomics a good shot at success.

Solazyme was named the Biofuels Digest “Company of the Year,” ranking number one on their list of the 50 Hottest Biofuels Companies. Solazyme has also announced a near-term focus on launching food products produced by algae, with a food oil similar to olive oil as a lead product. This probably stands a better chance of  near-term commercialization since the prices are about 25 times higher than for a fuel. The hope appears to be that cash flow from a large-volume food product will help fund even larger-volume fuel production.

Sapphire Energy is developing a product the company calls Green Crude. The product is green because it is produced by algae from sunlight and carbon dioxide. If successful, Sapphire’s crude product will be refineable into the three most important fuels in use today: gasoline, diesel, and jet fuel. With more than 100 employees and blue chip venture capital support, Sapphire bears watching.

Compared to bio-ethanol companies, algae companies have been lurking in the shadows, but they may be about ready to pounce.

Biofuels Digest released its 50 Hottest Biofuels Companies for this year and Solazyme is number 1, now well-established as a leader in the use of algae to produce biofuels. Read our  profile of Solazyme from March 22, 2009 here.

Algae has garnered a lot of attention as a biofuels source, but a big economic hurdle is collecting the oil-rich algae from ponds in which they are grown so that they can be processed to extract the fuel. LiveFuels has a novel approach to that problem: have fish eat the algae and recover and process the fish. The tag-line: biomass concentration as nature intended it. One algae expert called this approach “not impossible.” I also find it not unlikely that no funding will not be found from investors who are not unbelieving this not impossible approach.

Solazyme, which until now has positioned itself as a producer of biofuels from algae, has just announced a shift in focus to produce food oils. The company believes it can have products on the market in 2010.  According to chief technology officer Harrison Dillon, the decision to diversify into food products came about by almost by accident when scientists at the company discovered their algae could excrete oils that were similar to olive oil. Olive oil has a market price about 25 times higher than fuel; I’ll bet that also played a role in the decision.

Biofuels Digest has released its new rankings of biofuels companies. Here are the top 10, many of which have been profiled here in the past:

1 Solazyme,2 Poet, 3 Amyris, 4 BP Biofuels, 5 Sapphire Energy, 6 Coskata, 7 DuPont Danisco, 8 LS9, 9 Verenium, 10 Mascoma.

There were a few new names on the list: BP Biofuels was unranked last year and showed up at number 4 this year. Other newbies were further down the list.  Algae companies were strong this year, along with companies showing ability to scale up production for ethanol. We will take a closer look at some of these players in upcoming posts.

The cover story in the October 19, 2009 Wall Street Journal names 5 technologies that could, if successful, radically change the world energy picture, and next generation biofuels from algae is one of them. I would broaden the category to include designer microorganisms of the type being developed by Synthetic Genomics, but in general, I agree. Converting carbon dioxide into fuels using energy from the sun to drive the process would be a game-changer. Let’s hope it works out.

Any time an industry gets “hot” as has been the case for biofuels, spokespersons at the companies inevitably search for ways to differentiate their companies, products, and technologies. I’m not talking about hype or distortions, but rather the creative spin—names, words, and phrases—that are coined in an effort to make a company’s offerings stand out and be memorable.

I started thinking about this recently when I ran across a phrase on the web site of Joule Biotechnologies. According to the company’s web site, Joule is developing “SolarFuel^TM liquid energy.” I guess it just wouldn’t sound as impressive if they called it a fuel (and the company is assiduously eschewing the term biofuel). But if the so-called “ liquid energy” is not a fuel, what is it? And, just to be clear, the first “liquid energy” product Joule is aiming for is ethanol. This got me thinking that there must be other examples, and some I found are quite creative.

Below is a listing of some phrases from various biofuels companies, followed by my translation of what the phrase really means.

“Liquid Energy” (Joule Biotechnologies): biofuel such as ethanol

“99.7% pure ethanol” (Coskata): ethanol of similar purity to that made by every other bio-ethanol company, after refining

“Tightly protected Intellectual Property” (various): patents are pending

“Consolidated Bioprocessing Method” (Qteros): Their own particular sequence of bioprocessing steps to produce a biofuel

“The New Oil” (Range Fuels): biofuel (but really ethanol in this case)

“Green Crude” (Sapphire Energy): biofuel

“Pond to Pump” (Live Fuels): making biofuel from algae (I kind of like this one)

No Compromise^TM (Amyris): The trademarked name of Amyris’ new biodiesel product that is more like petroleum-based diesel (I like this one, too!)

If you have some other examples, please post in comments.

Exxon Mobil, which has avoided the biofuels frenzy so far, has finally made its entrance, and it is a grand one.  The oil giant has announced a $300 million investment to develop algae as a producer of hydrocarbons, which could then be processed in existing refineries. Exxon Mobil’s partner is notable as well–Craig Venter’s Synthetic Genomics. If all goes well, Venter’s company will engineer carbon dioxide-utilizing algae to produce and–the key step–then secrete the hydrocarbons to eliminate the need for isolating and breaking the cells. It is an ambitious goal, and if successful, a commercial home run.

GreenFuel Technologies Corporation, which planned to convert CO2 from smokestacks into fuel using algae, announced it is closing and put its assets up for sale. This is after spending more than $70 million in venture funding. I like this lead sentence from its web site announcing the offering of assets: “After leading the algae clean tech industry for the past 8 years …“. Leading the industry where?

Bluefire Ethanol has announced that it is partnering with Solazyme to pair its acid hydrolysis technology for producing fermentable sugars from biomass with Solazyme’s algae-based fuel production process. This is an interesting partnership. Solazyme wins only if fermentable sugars are cheaper this way. Bluefire wins if Solazyme can produce fuel at lower cost than Bluefire. Or is Bluefire acknowledging that it lacks a competitive ethanol production method, and is simply trying to create value from its biomass pre-treatment method?