This week I have been attending the conference on Development and Application of Enzymes in Biotechnology in Duesseldorf. It has been a great week for learning about the latest developments in enzymes and their applications, and in biocatalysis technology in particular, with a line-up of uniformly great speakers and timely topics.
The fun started before the full conference opened with a workshop I was asked to organize. We focused on the topic “Taking an Enzyme from Concept to Commercialization.” This was an opportunity to discuss the experiences across a range of industries, from companies large and small, in the commercialization process
Below I will highlight Seven Key Take-Aways from the Enzyme Workshop, one from each speaker.
- There is now a larger role for bioinformatics in new enzyme discovery. (Dr. Stefan Mix, Almac Sciences(
- It is possible to create a new enzyme activity starting with no activity with the aid of computational design. (Alexandre Zanghellini, Arzeda Corporation)
- Application testing of enzymes should be done early, and the earlier the better. (Joe McAuliffe, DuPont)
- There is a massive resistance to change of enzymes for in vitro diagnostics. The same enzymes have been used on some cases for 35-40 years. This creates a huge barrier to introduction of new enzymes in diagnostics. (Nick Major, Sekisui Diagnostics)
- Biocatalysis is moving to Pre-validated and Ready-to-Use or Plug and Play enzymes to shorten time-lines and reduce risk in scale-up and implementation. (Andreas Vogel, c-LEcta GmbH)
- Time-lines from concept to product have been consistently shrinking over the past 15 years. (Andy Ellis, Biocatalysts Ltd)
- Directed evolution will be mandatory for future innovation. (David Rozzell, Sustainable Chemistry Solutions, Inc.)