September 3, 2011
Read the full article →
About 25% of compounds in development contain fluorine. Why? Because fluorine-containing functionality often improves bioavailability and metabolic stability. For this reason, finding practical ways to introduce fluorine is attracting a lot of attention form chemists. Catylix, Inc. co-founded by Professor John Hartwig (previously at the University of Illinois where the technology was developed and patented; now at UC Berkeley) and Dr. David Rozzell (that’s me) is offering a new method for trifluoromethylation with unprecedented scope and functional group compatibility. The first product, a shelf-stable reagent for trifluoromethylation of aryl and vinyl iodides and bromides, was launched in July 2011 and is available through Aldrich.