Realizing the Future of Biocatalysis

March 18, 2014

Tweet The Informa Conference on Biocatalysis and the Industrial Applications of Enzymes starts today (March 18) with a workshop and goes through Thursday afternoon. David Rozzell is there, speaking today (Tuesday) and chairing the Wednesday session. The conference has an excellent group of speakers. I’ll be live blogging the conference and available for a meet-up […]

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Biocatalysis Enzyme Guide is Here!

February 23, 2014

Tweet Biocatalysis—the use of enzymes to catalyze chemical reactions—has gained in popularity in recent years, and for good reason. Biocatalysis works. Increasingly, enzymes are among the first choices of catalysts for a chemical reaction, no longer relegated to a back-up strategy to be considered when everything else has failed. The use of enzymes leads to […]

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Enzyme Sources Guide: Revised and Updated for 2014, Available Now

January 13, 2014

Tweet New suppliers and developers of enzymes are entering the market, and existing enzyme companies are expanding their offerings and capabilities. Smaller companies are being acquired by larger ones (BASF ‘s acquisition of Verenium or Novozymes’ acquisition of Allopartis are two recent examples), and large companies are merging to create even larger companies (for example: […]

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Aromatic Peroxygenase Structures

January 9, 2014

Tweet Aromatic peroxygenases have catalytic activity similar to that of cytochrome P450 monoxygenases (hydroxylation, S-oxidation, N-oxidation) on both aromatic and aliphatic substrates.  Unlike P450 monooxygenases, these enzymes have no need for NAD(P)H and complicated reductase domains and instead use hydrogen peroxide as the oxidant. The aromatic peroxygenase from the edible commercial mushroom, Agrocybe aegerita, is one of the well-studied enzymes […]

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Better Biocatalyst Reaction Schemes

December 20, 2013

Tweet Biocatalysts are increasingly being used by synthetic chemists.  For some reactions, such as stereoselective ketone reduction or resolution of carboxylic acids and esters, ketoreductases (KREDs) and lipases are well known and a first-line option.  However, there are a wide variety of enzymes that do useful chemistry that are not routinely used within the organic […]

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Omega Transaminase Review

December 19, 2013

Tweet Kroutil and co-workers have published a review on cascade reactions involving omega transaminases.  Cascade strategies are a powerful way to drive the equilibria of transaminase reactions, and the reductive amination of a substrate is often driven by concurrent enzymatic consumption of a co-product.  Many other cascades, for example the oxidation of an alcohol to a carbonyl followed by transaminase-mediated reduction […]

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John Cornforth and Enzyme Stereoselectivity

December 16, 2013

Tweet Sir John Cornforth passed away on December 14th, 2013.  Cornforth was a pioneer in the elucidation of the stereochemistry of enzyme reactions.  A chemist by training, Australian-born Cornforth contributed to the synthesis of steroids while conducting doctoral studies with Sir Robert Robinson at Oxford.  Cornforth’s independent research involved labeling enzyme substrates with deuterium and tritium using synthetic chemistry, generating isotopically-chiral […]

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Let’s Meet at Informex in Miami

December 12, 2013

Tweet Just a quick note to let everyone know that David Rozzell will be at Informex in January. If you would like to schedule a meeting, contact me by email: david@bio-catalyst.com And we have a special offer on the Enzyme Sources Guide through the end of December: All purchasers will get a free updated 2014 […]

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New Mainstream Biocatalysis Newsletter: Profiles on Verenium, Toluene Dioxygenase

December 3, 2013

Tweet The latest Mainstream Biocatalysis Newsletter came out this morning. In this issue we cover the latest company news, publications, and published patent applications. There are also two new profiles. The Company Profile is Verenium Corporation, which is timely since Verenium was recently acquired by BASF. The Enzyme Profile is toluene dioxygenase, an enzyme first […]

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Biocatalytic Retrosynthesis

November 4, 2013

Tweet E. J. Corey pioneered retrosynthetic analysis in organic synthesis, In fact, I was fortunate enough to take his course covering the subject in graduate school, and it was tour-de-force for synthetic organic chemists. Now, with biocatalysis surging and rightly staking a claim to be a viable option for chemical production, couldn’t the Corey concepts […]

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