Biocatalysis

With so much press (and hype) surrounding the biofuels industry, and so many new developments, understanding what is hot and what is not can be challenging. Ecofriend has tried to cut through the fog, listing their picks as the 10 Most Transformative Technologies of 2010. Follow the link for details. I’ll comment on some of these in upcoming posts.

I will make one observation now: Craig Venter’s creation of the first synthetic cell is not on the list–a gross oversight in my humble opinion.

Ethanol, and to a lesser extent biodiesel, have been the only biofuels products of note to be offered thus far. Why? For the simple reason that the technology already existed to make these products at a cost that allowed for commercialization without too large a subsidy. But, if one thinks about the ideal biofuel process, there is a much more attractive option being pursued at a number of early-stage biofuels developers.

Imagine a process that converts carbon dioxide–a greenhouse gas!–into a biofuel while growing in a pond or in sea water. This would be biofuels nirvana, and it may not be too far from becoming a reality.

Here are a few companies to watch.

Aurora Biofuels is using a genetically modified algae developed at the University of California at Berkeley to efficiently produce biodiesel using CO2 as the feedstock. The Aurora claims the technology can create biodiesel fuel competitive with $50 per barrel oil.

Synthetic Genomics approach does not use algae, but rather, specially created micro-organisms that are built by redesigning the genome almost form scratch. The ultimate goal is the conversion of carbon dioxide into fuels or commodity chemicals using energy from the sun to drive the process. Craig Venter, of genome-sequencing fame, leads this effort with up to $300 million in funding form Exxon Mobil. That kind of financial support gives Synthetic Genomics a good shot at success.

Solazyme was named the Biofuels Digest “Company of the Year,” ranking number one on their list of the 50 Hottest Biofuels Companies. Solazyme has also announced a near-term focus on launching food products produced by algae, with a food oil similar to olive oil as a lead product. This probably stands a better chance of  near-term commercialization since the prices are about 25 times higher than for a fuel. The hope appears to be that cash flow from a large-volume food product will help fund even larger-volume fuel production.

Sapphire Energy is developing a product the company calls Green Crude. The product is green because it is produced by algae from sunlight and carbon dioxide. If successful, Sapphire’s crude product will be refineable into the three most important fuels in use today: gasoline, diesel, and jet fuel. With more than 100 employees and blue chip venture capital support, Sapphire bears watching.

Compared to bio-ethanol companies, algae companies have been lurking in the shadows, but they may be about ready to pounce.

Biofuels Digest released its 50 Hottest Biofuels Companies for this year and Solazyme is number 1, now well-established as a leader in the use of algae to produce biofuels. Read our  profile of Solazyme from March 22, 2009 here.

South San Francisco-based LS9 announced today that it has developed a microbe that can produce advanced biofuels directly from cellulosic biomass, such as woodchips, in a “one-step” fermentation process that eliminates the need for additional chemicals and industrial processes.

Algae has garnered a lot of attention as a biofuels source, but a big economic hurdle is collecting the oil-rich algae from ponds in which they are grown so that they can be processed to extract the fuel. LiveFuels has a novel approach to that problem: have fish eat the algae and recover and process the fish. The tag-line: biomass concentration as nature intended it. One algae expert called this approach “not impossible.” I also find it not unlikely that no funding will not be found from investors who are not unbelieving this not impossible approach.

Solazyme, which until now has positioned itself as a producer of biofuels from algae, has just announced a shift in focus to produce food oils. The company believes it can have products on the market in 2010.  According to chief technology officer Harrison Dillon, the decision to diversify into food products came about by almost by accident when scientists at the company discovered their algae could excrete oils that were similar to olive oil. Olive oil has a market price about 25 times higher than fuel; I’ll bet that also played a role in the decision.

Biofuels Digest has released its new rankings of biofuels companies. Here are the top 10, many of which have been profiled here in the past:

1 Solazyme,2 Poet, 3 Amyris, 4 BP Biofuels, 5 Sapphire Energy, 6 Coskata, 7 DuPont Danisco, 8 LS9, 9 Verenium, 10 Mascoma.

There were a few new names on the list: BP Biofuels was unranked last year and showed up at number 4 this year. Other newbies were further down the list.  Algae companies were strong this year, along with companies showing ability to scale up production for ethanol. We will take a closer look at some of these players in upcoming posts.

In a press release yesterday Massachusetts-based Qteros, developer of the Q-microbe “”superbug” (actually Clostridium phytoferrans, but “Q” is much easier to pronounce and type).

The processes uses a material the company calls Recyllose-sewage sludge solids that are high is cellulose. Turning sewage sludge into ethanol offers a big opportunity for Qteros, which is partnering with Israel-based Applied CleanTech to develop the technology. Recyllose is a particularly good type of cellulosic feedstock as it contains very low amounts of lignin, the plant cell wall component that is difficult to degrade. Qteros-ACT scientists claim 120-135 gallons of ethanol per ton of Recyllose, and titers of 9% ethanol currently.

Quoting from the press release: “Our customer is every municipality that has a wastewater treatment plant,” said Jeff Hausthor, Qteros co-founder and senior project manager. “It will provide a value-added product for municipal wastewater plants, thereby making treatment plants much less expensive to run and helping local governments throughout the world with their constrained budgets.”

Israel Biran, ACT’s CEO, added, “It also helps answer the question of what municipalities can do with their sewage sludge, a major challenge now facing every wastewater treatment plant operator.”

There has been a PR blitz over the past 24 hours, and it appears to be well-merited.

What would you call a company that uses a microorganism to produce fuel? Well, according to Bill Sims, CEO of Joule Biotechnologies, not a biofuels company.

Sims was only announced as CEO of Joule yesterday, but he is wasting no time in trying to shine a public light on the company, although his comments are not always very illuminating. Joule has developed what it calls a HelioCulture system that concentrates sunlight and relies on a “highly engineered synthetic organism” that is unidentified but is “not algae” to convert CO₂ and nutrients to produce fuels and chemicals. But since no biomass is used, Sims is trying to avoid the “biofuels” moniker and what he considers to be the negative PR that comes with it.

The basic concept is termed “revolutionary” by Sims, and appears to be similar to that of Craig Venter’s company Synthetic Genomics, which recently announced a large commercialization agreement with Exxon Mobil.

According to Sims, Joule hasn’t worked out its business model yet, preferring to wait for the market to determine whether it is better to produce and sell fuels or license the technology to fuels producers, but that didn’t stop Flagship Ventures from making an initial investment that is termed “substantially less than $50 million.”

It all sounds great, but I see one drawback right away. Ethanol is planned to be the first product, and ethanol is a lousy fuel. And, I am sorry about this Bill, but I am tagging this post under biofuels and biofuels companies. I really wouldn’t know how else to categorize it.

GreenFuel Technologies Corporation, which planned to convert CO2 from smokestacks into fuel using algae, announced it is closing and put its assets up for sale. This is after spending more than $70 million in venture funding. I like this lead sentence from its web site announcing the offering of assets: “After leading the algae clean tech industry for the past 8 years …“. Leading the industry where?